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The duration of the trials was one year, with 480 patients exposed to Actonel 5 mg daily and 485 exposed to Actonel 35 mg once-a-week. Actonel should be taken according to the dosing instructions to minimize the risk of these events. 5% of patients in the Actonel 5 mg daily group and 14. 4% in the Actonel 75 mg two consecutive days per month group. The duration of the trial was two years; 613 patients were exposed to Actonel 5 mg daily and 616 were exposed to Actonel 75 mg two consecutive days per month.

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